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GPR62 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9BZJ7 |
| Other Accession | NP_543141.3 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 37614 Da |
| Antigen Region | 61-87 aa |
| Gene ID | 118442 |
|---|---|
| Other Names | Probable G-protein coupled receptor 62, G-protein coupled receptor GPCR8, hGPCR8, G-protein coupled receptor KPG_005, GPR62 |
| Target/Specificity | This GPR62 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 61-87 amino acids from the N-terminal region of human GPR62. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GPR62 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GPR62 |
|---|---|
| Function | Orphan G-protein coupled receptor. Constitutively activates the G(q/11)/inositol phosphate and the G(s)-alpha/cAMP signaling pathways (PubMed:28827538). Has spontaneous activity for beta-arrestin recruitment (PubMed:28827538). Shows a reciprocal modulation of signaling functions with the melatonin receptor MTNR1B most likely through receptor heteromerization (PubMed:28827538). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Note=Colocalizes with ARRB2 in the endosome (PubMed:28827538). |
| Tissue Location | Expressed in brain; detected in the basal forebrain, frontal cortex, caudate, putamen, thalamus and hippocampus |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
G protein-coupled receptors (GPCRs, or GPRs) contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.
References
Takeda, S., et al. FEBS Lett. 520 (1-3), 97-101 (2002) :
Lee, D.K., et al. Brain Res. Mol. Brain Res. 86 (1-2), 13-22 (2001) :
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