MND1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q9BWT6 |
Other Accession | NP_115493.1 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 23753 Da |
Antigen Region | 174-200 aa |
Gene ID | 84057 |
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Other Names | Meiotic nuclear division protein 1 homolog, MND1 {ECO:0000312|EMBL:EAX049641} |
Target/Specificity | This MND1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 174-200 amino acids from the C-terminal region of human MND1. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | MND1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | MND1 {ECO:0000312|EMBL:EAX04964.1} |
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Function | Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis (By similarity). Stimulates both DMC1- and RAD51-mediated homologous strand assimilation, which is required for the resolution of meiotic double- strand breaks. |
Cellular Location | Nucleus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The product of the MND1 gene associates with HOP2 (MIM 608665) to form a stable heterodimeric complex that binds DNA and stimulates the recombinase activity of RAD51 (MIM 179617) and DMC1 (MIM 602721) (Chi et al., 2007 [PubMed 17639080]). Both the MND1 and HOP2 genes are indispensable for meiotic recombination.
References
Rose, J. Phd, et al. Mol. Med. (2010) In press :
Chi, P., et al. Genes Dev. 21(14):1747-1757(2007)
Enomoto, R., et al. J. Biol. Chem. 281(9):5575-5581(2006)
Tsubouchi, H., et al. Mol. Cell. Biol. 22(9):3078-3088(2002)
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