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MOG Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q16653 |
| Other Accession | Q9BGS7, NP_001008229.1 |
| Reactivity | Human |
| Predicted | Monkey |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 28193 Da |
| Antigen Region | 82-109 aa |
| Gene ID | 4340 |
|---|---|
| Other Names | Myelin-oligodendrocyte glycoprotein, MOG |
| Target/Specificity | This MOG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 82-109 amino acids from the Central region of human MOG. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MOG Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MOG |
|---|---|
| Function | Mediates homophilic cell-cell adhesion (By similarity). Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication. |
| Cellular Location | [Isoform 1]: Cell membrane; Multi- pass membrane protein [Isoform 2]: Cell membrane; Single- pass type I membrane protein [Isoform 4]: Cell membrane; Single- pass type I membrane protein [Isoform 7]: Cell membrane; Single- pass type I membrane protein [Isoform 9]: Cell membrane; Single- pass type I membrane protein |
| Tissue Location | Found exclusively in the CNS, where it is localized on the surface of myelin and oligodendrocyte cytoplasmic membranes |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The product of this gene is a membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths. Due to this localization, it is a primary target antigen involved in immune-mediated demyelination. This protein may be involved in completion and maintenance of the myelin sheath and in cell-cell communication. Alternatively spliced transcript variants encoding different isoforms have been identified.
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Boyle, L.H., et al. J. Neurochem. 102(6):1853-1862(2007)
Allamargot, C., et al. J. Neurochem. 101(2):298-312(2007)
Delarasse, C., et al. J. Neurochem. 98(6):1707-1717(2006)
Ballenthin, P.A., et al. J. Neurosci. Res. 46(2):271-281(1996)
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