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ORNT2 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9BXI2 |
| Other Accession | NP_114153.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 32580 Da |
| Antigen Region | 78-107 aa |
| Gene ID | 83884 |
|---|---|
| Other Names | Mitochondrial ornithine transporter 2, Solute carrier family 25 member 2, SLC25A2, ORNT2 |
| Target/Specificity | This ORNT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 78-107 amino acids from the Central region of human ORNT2. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ORNT2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SLC25A2 (HGNC:22921) |
|---|---|
| Function | Mitochondrial transporter of the positively charged amino acids ornithine, lysine and arginine, and the neutral amino acid citrulline (PubMed:12807890). In addition, transports the basic amino acids histidine, homoarginine, and asymmetric dimethylarginine (aDMA), but not symmetric DMA, and the D-forms of lysine, arginine, ornithine and histidine (PubMed:12807890, PubMed:26403849). Functions by both counter-exchange and uniport mechanisms (PubMed:26403849). |
| Cellular Location | Mitochondrion membrane; Multi-pass membrane protein. Mitochondrion inner membrane; Multi-pass membrane protein |
| Tissue Location | Expressed in liver, testis, spleen, lung, pancreas, and small intestine and expressed poorly in other tissues |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Located between the protocadherin beta and gamma gene clusters on chromosome 5, this intronless gene encodes a protein that is highly similar to an ornithine transporter localized in the mitochondrial inner membrane. The encoded protein most likely plays a role in metabolism as a mitochondrial transport protein.
References
Trynka, G., et al. Gut 58(8):1078-1083(2009)
Fiermonte, G., et al. J. Biol. Chem. 278(35):32778-32783(2003)
Camacho, J.A., et al. Mol. Genet. Metab. 79(4):257-271(2003)
Wu, Q., et al. Genome Res. 11(3):389-404(2001)
Porter, R.K. Biochim. Biophys. Acta 1459 (2-3), 356-362 (2000) :
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