PCMTD1 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 2
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | Q96MG8 |
Other Accession | P59913, Q5ZMR3, A2VDP2, NP_443169.2 |
Reactivity | Human, Mouse |
Predicted | Bovine, Chicken |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 40675 Da |
Antigen Region | 19-48 aa |
Gene ID | 115294 |
---|---|
Other Names | Protein-L-isoaspartate O-methyltransferase domain-containing protein 1, PCMTD1 |
Target/Specificity | This PCMTD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 19-48 amino acids from the N-terminal region of human PCMTD1. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | PCMTD1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | PCMTD1 (HGNC:30483) |
---|---|
Function | Substrate recognition component of an ECS (Elongin BC-CUL5- SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:35486881). Specifically binds to the methyltransferase cofactor S-adenosylmethionine (AdoMet) via the N-terminal AdoMet binding motif, but does not display methyltransferase activity (PubMed:35486881). May provide an alternate maintenance pathway for modified proteins by acting as a damage-specific E3 ubiquitin ligase adaptor protein (PubMed:35486881). |
Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:P22061}. Membrane; Lipid-anchor |
Provided below are standard protocols that you may find useful for product applications.
Background
PCMTD1 belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
References
Rose, J. Phd, et al. Mol. Med. (2010) In press :
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.