Foundational characteristics of cancer include proliferation, angiogenesis, migration, evasion of apoptosis, and cellular immortality. Find key markers for these cellular processes and antibodies to detect them.
The SUMOplot™ Analysis Program predicts and scores sumoylation sites in your protein. SUMOylation is a post-translational modification involved in various cellular processes, such as nuclear-cytosolic transport, transcriptional regulation, apoptosis, protein stability, response to stress, and progression through the cell cycle.
The Autophagy Receptor Motif Plotter predicts and scores autophagy receptor binding sites in your protein. Identifying proteins connected to this pathway is critical to understanding the role of autophagy in physiological as well as pathological processes such as development, differentiation, neurodegenerative diseases, stress, infection, and cancer.
NAALADL1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9UQQ1 |
| Other Accession | NP_005459.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 80558 Da |
| Antigen Region | 511-539 aa |
| Gene ID | 10004 |
|---|---|
| Other Names | N-acetylated-alpha-linked acidic dipeptidase-like protein, NAALADase L, 100 kDa ileum brush border membrane protein, I100, Ileal dipeptidylpeptidase, NAALADL1, NAALADASEL, NAALADL |
| Target/Specificity | This NAALADL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 511-539 amino acids from the C-terminal region of human NAALADL1. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | NAALADL1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NAALADL1 |
|---|---|
| Synonyms | NAALADASEL, NAALADL {ECO:0000303|PubMed: |
| Function | Aminopeptidase with broad substrate specificity. Has lower activity with substrates that have Asp or Glu in the P2' position, or Pro in the P3' position. Lacks activity with substrates that have both Pro in the P3' position and Asp or Glu in the P2' position (PubMed:25752612). Lacks carboxypeptidase activity. Lacks dipeptidyl- peptidase IV type activity (PubMed:25752612). |
| Cellular Location | Apical cell membrane {ECO:0000250|UniProtKB:O54697}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:O54697}. Note=Ileal brush border membrane {ECO:0000250|UniProtKB:O54697} |
| Tissue Location | Detected in small intestine (at protein level) (PubMed:25752612). Detected in ileum (PubMed:9388249). Detected in small intestine, spleen and testis. Isoform 2 and isoform 3 are found in the small intestine and colon (PubMed:10085079) |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
NAALADase-like activity unknown. It has no NAAG hydrolyzing activity. Exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC (By similarity).
References
Pangalos, M.N., et al. J. Biol. Chem. 274(13):8470-8483(1999)
Shneider, B.L., et al. J. Biol. Chem. 272(49):31006-31015(1997)
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.
Ordering Information
Shipping Information
