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TCF15 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q12870 |
| Other Accession | Q60756, P79782, NP_004600.2 |
| Reactivity | Human |
| Predicted | Chicken, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 20816 Da |
| Antigen Region | 81-107 aa |
| Gene ID | 6939 |
|---|---|
| Other Names | Transcription factor 15, TCF-15, Class A basic helix-loop-helix protein 40, bHLHa40, Paraxis, Protein bHLH-EC2, TCF15, BHLHA40, BHLHEC2 |
| Target/Specificity | This TCF15 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 81-107 amino acids from the Central region of human TCF15. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TCF15 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TCF15 (HGNC:11627) |
|---|---|
| Function | Early transcription factor that plays a key role in somitogenesis, paraxial mesoderm development and regulation of stem cell pluripotency. Essential for the mesenchymal to epithelial transition associated with somite formation. Required for somite morphogenesis, thereby regulating patterning of the axial skeleton and skeletal muscles. Required for proper localization of somite epithelium markers during the mesenchymal to epithelial transition. Also plays a key role in regulation of stem cell pluripotency. Promotes pluripotency exit of embryonic stem cells (ESCs) by priming ESCs for differentiation. Acts as a key regulator of self-renewal of hematopoietic stem cells (HSCs) by mediating HSCs quiescence and long- term self-renewal. Together with MEOX2, regulates transcription in heart endothelial cells to regulate fatty acid transport across heart endothelial cells. Acts by forming a heterodimer with another helix- loop-helix (bHLH) protein, such as TCF3/E12, that binds DNA on E-box motifs (5'-CANNTG-3') and activates transcription of target genes. |
| Cellular Location | Nucleus {ECO:0000250|UniProtKB:Q60756, ECO:0000255|PROSITE-ProRule:PRU00981} |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is found in the nucleus and may be involved in the early transcriptional regulation of patterning of the mesoderm. The encoded basic helix-loop-helix protein requires dimerization with another basic helix-loop-helix protein for efficient DNA binding.
References
Guo, P., et al. J. Biol. Chem. 284(27):18184-18193(2009)
Deloukas, P., et al. Nature 414(6866):865-871(2001)
Hidai, H., et al. Genomics 30(3):598-601(1995)
Quertermous, E.E., et al. Proc. Natl. Acad. Sci. U.S.A. 91(15):7066-7070(1994)
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