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DRAM Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, E |
|---|---|
| Primary Accession | Q8N682 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 26253 Da |
| Antigen Region | 176-206 aa |
| Gene ID | 55332 |
|---|---|
| Other Names | DNA damage-regulated autophagy modulator protein 1, Damage-regulated autophagy modulator, DRAM1, DRAM |
| Target/Specificity | This DRAM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 176~206 amino acids from the C-terminal region of human DRAM. |
| Dilution | IHC-P~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | DRAM Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | DRAM1 |
|---|---|
| Synonyms | DRAM |
| Function | Lysosomal modulator of autophagy that plays a central role in p53/TP53-mediated apoptosis. Not involved in p73/TP73-mediated autophagy. |
| Cellular Location | Lysosome membrane; Multi-pass membrane protein |
Provided below are standard protocols that you may find useful for product applications.
Background
DRAM is regulated as part of the p53 tumor suppressor pathway. It is a lysosomal membrane protein that is required for the induction of autophagy by the pathway. Decreased transcriptional expression of this protein is associated with various tumors.
References
Kerley-Hamilton,J.S., Biochim. Biophys. Acta 1769 (4), 209-219 (2007)
Crighton,D., Autophagy 3 (1), 72-74 (2007)
Crighton,D., Cell 126 (1), 121-134 (2006)
Green,D.R., Cell 126 (1), 30-32 (2006)
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