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PADI6 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q6TGC4 |
| Other Accession | NP_997304.3 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 77727 Da |
| Antigen Region | 196-223 aa |
| Gene ID | 353238 |
|---|---|
| Other Names | Protein-arginine deiminase type-6, Peptidyl arginine deiminase-like protein, Peptidylarginine deiminase VI, hPADVI, Protein-arginine deiminase type VI, PADI6 |
| Target/Specificity | This PADI6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 196-223 amino acids from the N-terminal region of human PADI6. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PADI6 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PADI6 {ECO:0000303|PubMed:15087120, ECO:0000312|HGNC:HGNC:20449} |
|---|---|
| Function | Structural constituent of cytoplasmic lattices, which plays a key role in early embryonic development (PubMed:37922900). Cytoplasmic lattices consist in fibrous structures found in the cytoplasm of oocytes and preimplantation embryos (PubMed:37922900). They are required to store maternal proteins critical for embryonic development, such as ribosomal proteins and proteins that control epigenetic reprogramming of the preimplantation embryo, and prevent their degradation or activation (PubMed:37922900). In contrast to other members of the family, does not show protein-arginine deiminase activity due to its inability to bind Ca(2+) (PubMed:38656308, PubMed:39286527). |
| Cellular Location | Cytoplasm. Cytoplasmic vesicle, secretory vesicle, Cortical granule {ECO:0000250|UniProtKB:Q8K3V4}. Nucleus {ECO:0000250|UniProtKB:Q8K3V4}. Note=Core component of cytoplasmic lattices in oocytes (PubMed:37922900). Also nuclear (By similarity) {ECO:0000250|UniProtKB:Q8K3V4, ECO:0000269|PubMed:37922900} |
| Tissue Location | Highly expressed in oocytes and weakly expressed in other somatic tissues. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Peptidylarginine deiminases (PADs, EC 3.5.3.15), including PADI6, make up a family of posttranslational protein modification enzymes that convert arginine residues to citrulline residues in the presence of calcium ions.
References
Stacey, S.N., et al. Nat. Genet. 40(11):1313-1318(2008)
Chavanas, S., et al. Gene 330, 19-27 (2004) :
Zhang, J., et al. Acta Biochim. Pol. 51(4):1051-1058(2004)
Vossenaar, E.R., et al. Bioessays 25(11):1106-1118(2003)
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