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PADI6 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q6TGC4 |
| Other Accession | NP_997304.3 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 77727 Da |
| Antigen Region | 196-223 aa |
| Gene ID | 353238 |
|---|---|
| Other Names | Protein-arginine deiminase type-6, Peptidyl arginine deiminase-like protein, Peptidylarginine deiminase VI, hPADVI, Protein-arginine deiminase type VI, PADI6 |
| Target/Specificity | This PADI6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 196-223 amino acids from the N-terminal region of human PADI6. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PADI6 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PADI6 |
|---|---|
| Synonyms | PAD6 |
| Function | Catalyzes the deimination of arginine residues of proteins (By similarity). May be involved in cytoskeletal reorganization in the egg and early embryo (PubMed:27545678). |
| Cellular Location | Cytoplasm. Nucleus {ECO:0000250|UniProtKB:Q8K3V4}. Cytoplasmic vesicle, secretory vesicle, Cortical granule {ECO:0000250|UniProtKB:Q8K3V4}. Note=Predominantly cytoplasmic (oocyte cytoplasmic sheets), also nuclear. Released extracellularly during the cortical reaction, and remains associated with the blastomeres surfaces as a peripheral membrane protein until the blastocyst stage of development. {ECO:0000250|UniProtKB:Q8K3V4} |
| Tissue Location | Highly expressed in oocytes and weakly expressed in other somatic tissues. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Peptidylarginine deiminases (PADs, EC 3.5.3.15), including PADI6, make up a family of posttranslational protein modification enzymes that convert arginine residues to citrulline residues in the presence of calcium ions.
References
Stacey, S.N., et al. Nat. Genet. 40(11):1313-1318(2008)
Chavanas, S., et al. Gene 330, 19-27 (2004) :
Zhang, J., et al. Acta Biochim. Pol. 51(4):1051-1058(2004)
Vossenaar, E.R., et al. Bioessays 25(11):1106-1118(2003)
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