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KCNAB3 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | O43448 |
| Other Accession | NP_004723.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 43670 Da |
| Antigen Region | 176-204 aa |
| Gene ID | 9196 |
|---|---|
| Other Names | Voltage-gated potassium channel subunit beta-3, K(+) channel subunit beta-3, Kv-beta-3, KCNAB3, KCNA3B |
| Target/Specificity | This KCNAB3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 176-204 amino acids from the Central region of human KCNAB3. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | KCNAB3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | KCNAB3 (HGNC:6230) |
|---|---|
| Synonyms | KCNA3B |
| Function | Regulatory subunit of the voltage-gated potassium (Kv) channels composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunit (PubMed:9857044). The beta- 3/KCNAB3 subunit may mediate closure of potassium channels (By similarity). Increases inactivation of Kv1.5/KCNA5 alpha subunit- containing channels (PubMed:9857044). May display nicotinamide adenine dinucleotide phosphate (NADPH)-dependent aldoketoreductase activity (By similarity). The binding of oxidized and reduced NADP(H) cofactors may be required for the regulation of potassium channel activity (By similarity). |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q14722}. |
| Tissue Location | Brain specific. Most prominent expression in cerebellum. Weaker signals detected in cortex, occipital lobe, frontal lobe and temporal lobe. Not detected in spinal cord, heart, lung, liver, kidney, pancreas, placenta and skeletal muscle |
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Provided below are standard protocols that you may find useful for product applications.
Background
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member is one of the beta subunits, which are auxiliary proteins associating with functional Kv-alpha subunits. This member and the KCNA5 gene product assemble into a heteromultimeric A-type channel that inactivates completely and is significantly faster than other A-type Kv channels.
References
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Leicher, T., et al. J. Biol. Chem. 273(52):35095-35101(1998)
McCormack, K., et al. FEBS Lett. 370 (1-2), 32-36 (1995) :
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