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Mouse Kcnj11 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q61743 |
| Other Accession | O02822, Q14654, NP_034732.1 |
| Reactivity | Human, Mouse |
| Predicted | Rabbit |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 43562 Da |
| Antigen Region | 1-27 aa |
| Gene ID | 16514 |
|---|---|
| Other Names | ATP-sensitive inward rectifier potassium channel 11, Inward rectifier K(+) channel Kir62, Potassium channel, inwardly rectifying subfamily J member 11, Kcnj11 |
| Target/Specificity | This Mouse Kcnj11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-27 amino acids from the N-terminal region of mouse Kcnj11. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Mouse Kcnj11 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Kcnj11 |
|---|---|
| Function | This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium. Can form cardiac and smooth muscle-type KATP channels with ABCC9. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation (By similarity). |
| Cellular Location | Membrane; Multi-pass membrane protein. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium (By similarity).
References
Hugill, A., et al. Diabetologia 53(11):2352-2356(2010)
Li, J., et al. J. Biol. Chem. 285(37):28723-28730(2010)
Marhfour, I., et al. Cell Tissue Res. 340(2):335-346(2010)
Kurata, H.T., et al. PLoS Biol. 8 (2), E1000315 (2010) :
Alekseev, A.E., et al. Cell Metab. 11(1):58-69(2010)
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