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SEC23B Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q15437 |
| Other Accession | Q9D662, Q3SZN2, NP_001166216.1 |
| Reactivity | Human |
| Predicted | Bovine, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 86479 Da |
| Antigen Region | 655-684 aa |
| Gene ID | 10483 |
|---|---|
| Other Names | Protein transport protein Sec23B, SEC23-related protein B, SEC23B |
| Target/Specificity | This SEC23B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 655-684 amino acids from the C-terminal region of human SEC23B. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SEC23B Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SEC23B (HGNC:10702) |
|---|---|
| Function | Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex. |
| Cellular Location | Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000250|UniProtKB:Q15436}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q15436}; Cytoplasmic side {ECO:0000250|UniProtKB:Q15436}. Endoplasmic reticulum membrane; Peripheral membrane protein {ECO:0000250|UniProtKB:Q15436}; Cytoplasmic side {ECO:0000250|UniProtKB:Q15436}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q15436} |
| Tissue Location | Ubiquitously expressed. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a member of the SEC23 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec23p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The function of this gene product has been implicated in cargo selection and concentration. Multiple alternatively spliced transcript variants have been identified in this gene.
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Fermo, E., et al. Blood Cells Mol. Dis. 45(1):20-22(2010)
Bianchi, P., et al. Hum. Mutat. 30(9):1292-1298(2009)
Schwarz, K., et al. Nat. Genet. 41(8):936-940(2009)
Oh, J.H., et al. Mamm. Genome 16(12):942-954(2005)
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