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ASTE1 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q2TB18 |
| Other Accession | NP_054784.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 77093 Da |
| Antigen Region | 29-55 aa |
| Gene ID | 28990 |
|---|---|
| Other Names | Protein asteroid homolog 1, ASTE1 |
| Target/Specificity | This ASTE1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 29-55 amino acids from the N-terminal region of human ASTE1. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ASTE1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ASTE1 |
|---|---|
| Function | Structure-specific DNA endonuclease that specifically cleaves single-stranded DNA and 3' overhang DNA. Contributes to the control of DNA double-strand break repair choice by antagonizing BRCA1-dependent homologous recombination (HR) and promoting non-homologous end-joining (NHEJ). Recruited to the single-stranded DNA ends by SHLD2 and cleaves the 3' exposed DNA ends, therefore inhibiting DNA end resection (necessary for HR) and promoting DNA end protection (necessary for NHEJ). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
ASTE1 is possible role in EGF receptor signaling (By similarity).
References
Tougeron, D., et al. Mod. Pathol. 22(9):1186-1195(2009)
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