IRX6 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | P78412 |
Other Accession | NP_077311.2 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 48240 Da |
Antigen Region | 260-288 aa |
Gene ID | 79190 |
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Other Names | Iroquois-class homeodomain protein IRX-6, Homeodomain protein IRXB3, Iroquois homeobox protein 6, IRX6, IRX7, IRXB3 |
Target/Specificity | This IRX6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 260-288 amino acids from the Central region of human IRX6. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | IRX6 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | IRX6 |
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Synonyms | IRX7, IRXB3 |
Function | Transcription factor. Binds to the iroquois binding site (IBS) motif of target genes to regulate gene expression; functions as a transcriptional activator or repressor. Modulates expression of RCVRN, VSX1, BHLHE22/BHLHB5 and TACR3/Nk3r. Required downstream of retinal bipolar cell specification for the terminal differentiation of type 2, type 3a and possibly type 6 bipolar cells. |
Cellular Location | Nucleus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The function of this protein remains unknown.
References
Ogura, K., et al. Cytogenet. Cell Genet. 92 (3-4), 320-325 (2001) :
Lewis, M.T., et al. Cell Tissue Res. 296(3):549-554(1999)
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