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G2E3 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q7L622 |
| Other Accession | Q4R9C4, NP_060239.2 |
| Reactivity | Human |
| Predicted | Monkey |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 80504 Da |
| Antigen Region | 226-252 aa |
| Gene ID | 55632 |
|---|---|
| Other Names | G2/M phase-specific E3 ubiquitin-protein ligase, 632-, G2E3, KIAA1333 |
| Target/Specificity | This G2E3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 226-252 amino acids from the Central region of human G2E3. |
| Dilution | WB~~1:2000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | G2E3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | G2E3 |
|---|---|
| Synonyms | KIAA1333 |
| Function | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Essential in early embryonic development to prevent apoptotic death. |
| Cellular Location | Nucleus, nucleolus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm. In the nucleus, delocalizes from the nucleolus to the nucleoplasm in response to DNA damage |
| Tissue Location | Predominantly expressed in brain, liver, kidney, testes and ovary. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Essential in early embryonic development to prevent apoptotic death.
References
Brooks, W.S., et al. J. Biol. Chem. 283(32):22304-22315(2008)
Brooks, W.S., et al. Exp. Cell Res. 313(4):665-676(2007)
Lehner, B., et al. Genomics 83(1):153-167(2004)
Crawford, D.F., et al. J. Biol. Chem. 276(40):37166-37177(2001)
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