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CLEC2D Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9UHP7 |
| Other Accession | NP_001004419.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 21849 Da |
| Antigen Region | 109-137 aa |
| Gene ID | 29121 |
|---|---|
| Other Names | C-type lectin domain family 2 member D, Lectin-like NK cell receptor, Lectin-like transcript 1, LLT-1, Osteoclast inhibitory lectin, CLEC2D, CLAX, LLT1, OCIL |
| Target/Specificity | This CLEC2D antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 109-137 amino acids from the Central region of human CLEC2D. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CLEC2D Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CLEC2D |
|---|---|
| Synonyms | CLAX, LLT1, OCIL |
| Function | Receptor for KLRB1 that protects target cells against natural killer cell-mediated lysis (PubMed:16339513, PubMed:20843815). Inhibits osteoclast formation (PubMed:14753741, PubMed:15123656). Inhibits bone resorption (PubMed:14753741). Modulates the release of interferon-gamma (PubMed:15104121). Binds high molecular weight sulfated glycosaminoglycans (PubMed:15123656). |
| Cellular Location | Cell membrane; Single-pass type II membrane protein [Isoform 4]: Endoplasmic reticulum |
| Tissue Location | Detected in peripheral blood leukocytes, osteoblasts, lymph node, thymus and spleen. Isoform 1, isoform 2 and isoform 4 are expressed in T- and B-lymphocytes, and at lower levels in NK cells. They are also expressed in B-cell lines and LPS-matured monocyte-derived dendritic cells. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the natural killer cell receptor C-type lectin family. The encoded protein inhibits osteoclast formation and contains a transmembrane domain near the N-terminus as well as the C-type lectin-like extracellular domain. Several alternatively spliced transcript variants have been identified for this gene.
References
Germain, C., et al. J. Biol. Chem. (2010) In press :
Bambard, N.D., et al. Scand. J. Immunol. 71(3):210-219(2010)
Skinningsrud, B., et al. J. Clin. Endocrinol. Metab. 93(9):3310-3317(2008)
Rosen, D.B., et al. J. Immunol. 180(10):6508-6517(2008)
Pineda, B., et al. Calcif. Tissue Int. 82(5):348-353(2008)
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