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GCHFR Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P30047 |
| Other Accession | Q32L41, NP_005249.1 |
| Reactivity | Human |
| Predicted | Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 9698 Da |
| Antigen Region | 38-66 aa |
| Gene ID | 2644 |
|---|---|
| Other Names | GTP cyclohydrolase 1 feedback regulatory protein, GFRP, GTP cyclohydrolase I feedback regulatory protein, p35, GCHFR, GFRP |
| Target/Specificity | This GCHFR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 38-66 amino acids from the C-terminal region of human GCHFR. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GCHFR Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GCHFR |
|---|---|
| Synonyms | GFRP |
| Function | Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine. |
| Cellular Location | Nucleus. Nucleus membrane. Cytoplasm, cytosol |
| Tissue Location | In epidermis, expressed predominantly in basal undifferentiated keratinocytes and in some but not all melanocytes (at protein level). |
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Provided below are standard protocols that you may find useful for product applications.
Background
GTP cyclohydrolase I feedback regulatory protein binds to and mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase I. The regulatory protein, GCHFR, consists of a homodimer. It is postulated that GCHFR may play a role in regulating phenylalanine metabolism in the liver and in the production of biogenic amine neurotransmitters and nitric oxide.
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010) McHugh, P.C., et al. Pharmacogenomics J. (2010) In press : Li, L., et al. Circ. Res. 106(2):328-336(2010) Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009) Schnetz-Boutaud, N.C., et al. Genes Brain Behav. 8(8):753-757(2009)
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