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TRIM58 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q8NG06 |
| Other Accession | NP_056246.3 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 54766 Da |
| Antigen Region | 457-486 aa |
| Gene ID | 25893 |
|---|---|
| Other Names | E3 ubiquitin-protein ligase TRIM58, 632-, Protein BIA2, Tripartite motif-containing protein 58, TRIM58 |
| Target/Specificity | This TRIM58 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 457-486 amino acids from the C-terminal region of human TRIM58. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TRIM58 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TRIM58 |
|---|---|
| Function | E3 ubiquitin ligase induced during late erythropoiesis. Directly binds and ubiquitinates the intermediate chain of the microtubule motor dynein (DYNC1LI1/DYNC1LI2), stimulating the degradation of the dynein holoprotein complex. May participate in the erythroblast enucleation process through regulation of nuclear polarization. |
| Tissue Location | Expressed in erythroblasts. |
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Provided below are standard protocols that you may find useful for product applications.
Background
TRIM58 belongs to the TRIM/RBCC family of proteins. it contains a B box-type zinc finger domain, a B30.2/SPRY domain and a RING-type zinc finger domian.
References
Kamatani, Y., et al. Nat. Genet. 42(3):210-215(2010)
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