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RAB4B Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P61018 |
| Other Accession | P51146, Q91ZR1, Q68EK7, NP_057238.3 |
| Reactivity | Human |
| Predicted | Zebrafish, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 23587 Da |
| Antigen Region | 29-58 aa |
| Gene ID | 53916 |
|---|---|
| Other Names | Ras-related protein Rab-4B, RAB4B |
| Target/Specificity | This RAB4B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 29-58 amino acids from the N-terminal region of human RAB4B. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | RAB4B Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RAB4B (HGNC:9782) |
|---|---|
| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB4B mediates endosomal tethering and fusion through the interaction with RUFY1 and RAB14 (PubMed:20534812). Acts as a regulator of platelet alpha-granule release during activation and aggregation of platelets (By similarity). |
| Cellular Location | Cell membrane; Lipid-anchor; Cytoplasmic side. Early endosome membrane; Lipid-anchor; Cytoplasmic side |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
RAB proteins, such as RAB4B, are members of the RAS superfamily of small GTPases that are involved in vesicular trafficking (He et al., 2002 [PubMed 12450215]).
References
Kaddai, V., et al. PLoS ONE 4 (4), E5257 (2009) :
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Wan, D., et al. Proc. Natl. Acad. Sci. U.S.A. 101(44):15724-15729(2004)
He, H., et al. Gene Expr. 10 (5-6), 231-242 (2002) :
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