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RNASE2 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P10153 |
| Other Accession | NP_002925.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 18354 Da |
| Antigen Region | 124-152 aa |
| Gene ID | 6036 |
|---|---|
| Other Names | Non-secretory ribonuclease, Eosinophil-derived neurotoxin, RNase UpI-2, Ribonuclease 2, RNase 2, Ribonuclease US, RNASE2, EDN, RNS2 |
| Target/Specificity | This RNASE2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 124-152 amino acids from the C-terminal region of human RNASE2. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | RNASE2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RNASE2 |
|---|---|
| Synonyms | EDN, RNS2 |
| Function | This is a non-secretory ribonuclease. It is a pyrimidine specific nuclease with a slight preference for U. Cytotoxin and helminthotoxin. Selectively chemotactic for dendritic cells. Possesses a wide variety of biological activities. |
| Cellular Location | Lysosome. Cytoplasmic granule. Note=Matrix of eosinophil's large specific granule |
| Tissue Location | Liver, lung, spleen, leukocytes and body fluids. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This is a non-secretory ribonuclease. It is a pyrimidine specific nuclease with a slight preference for U. Cytotoxin and helminthotoxin. Selectively chemotactic for dendritic cells. Possesses a wide variety of biological activities.
References
McGovern, D.P., et al. Hum. Mol. Genet. 19(17):3468-3476(2010)
Plager, D.A., et al. J. Immunol. 183(6):4013-4020(2009)
Wang, H.Y., et al. J. Cell. Biochem. 106(2):317-326(2009)
Ueki, M., et al. Cell Biochem. Funct. 26(6):718-722(2008)
Parwez, Q., et al. J Negat Results Biomed 7, 9 (2008) :
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