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CDC42EP1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q00587 |
| Other Accession | NP_689449.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 40295 Da |
| Antigen Region | 315-343 aa |
| Gene ID | 11135 |
|---|---|
| Other Names | Cdc42 effector protein 1, Binder of Rho GTPases 5, Serum protein MSE55, CDC42EP1, BORG5, CEP1, MSE55 |
| Target/Specificity | This CDC42EP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 315-343 amino acids from the C-terminal region of human CDC42EP1. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CDC42EP1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CDC42EP1 |
|---|---|
| Synonyms | BORG5, CEP1, MSE55 |
| Function | Probably involved in the organization of the actin cytoskeleton. Induced membrane extensions in fibroblasts. |
| Cellular Location | Endomembrane system; Peripheral membrane protein. Cytoplasm, cytoskeleton |
| Tissue Location | Endothelial and bone marrow stromal cells. |
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Provided below are standard protocols that you may find useful for product applications.
Background
CDC42 is a member of the Rho GTPase family that regulates multiple cellular activities, including actin polymerization. The protein encoded by this gene is a CDC42 binding protein that mediates actin cytoskeleton reorganization at the plasma membrane. This protein is secreted and is primarily found in bone marrow.
References
Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Zhang, J., et al. Mol. Biol. Cell 16(2):824-834(2005)
Ballif, B.A., et al. Mol. Cell Proteomics 3(11):1093-1101(2004)
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