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RASA3 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q14644 |
| Other Accession | NP_031394.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 95699 Da |
| Antigen Region | 594-623 aa |
| Gene ID | 22821 |
|---|---|
| Other Names | Ras GTPase-activating protein 3, GAP1(IP4BP), Ins P4-binding protein, RASA3 |
| Target/Specificity | This RASA3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 594-623 amino acids from the C-terminal region of human RASA3. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | RASA3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RASA3 |
|---|---|
| Function | Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4) with high affinity. Might be a specific IP4 receptor. |
| Cellular Location | Cell membrane. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This family member is an inositol 1,3,4,5-tetrakisphosphate-binding protein, like the closely related RAS p21 protein activator 2. The two family members have distinct pleckstrin-homology domains, with this particular member having a domain consistent with its localization to the plasma membrane.
References
Kupzig, S., et al. Mol. Cell. Biol. 29(14):3929-3940(2009)
Rush, J., et al. Nat. Biotechnol. 23(1):94-101(2005)
Walker, S.A., et al. J. Biol. Chem. 277(50):48779-48785(2002)
Koehler, J.A., et al. Biochem. Biophys. Res. Commun. 283(4):888-895(2001)
Cozier, G.E., et al. J. Biol. Chem. 275(36):28261-28268(2000)
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