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GATSL2 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P-Leica, WB, E |
|---|---|
| Primary Accession | A6NHX0 |
| Other Accession | Q8NAP1, Q5BJZ0, Q9CWQ8, Q8WTX7, Q0V8A3, Q8CAB8, A6NHX0, Q6DDW7, NP_001138535.1 |
| Reactivity | Human |
| Predicted | Bovine, Mouse, Rat, Xenopus |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 36056 Da |
| Antigen Region | 25-51 aa |
| Gene ID | 729438 |
|---|---|
| Other Names | GATS-like protein 2, GATL2 |
| Target/Specificity | This GATSL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 25-51 amino acids from the N-terminal region of human GATSL2. |
| Dilution | IHC-P-Leica~~1:250 WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GATSL2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CASTOR2 {ECO:0000303|PubMed:26972053, ECO:0000312|HGNC:HGNC:37073} |
|---|---|
| Function | Functions as a negative regulator of the TORC1 signaling pathway through the GATOR complex. As part of homodimers or heterodimers with CASTOR1, directly binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Does not directly bind arginine, but binding of arginine to CASTOR1 disrupts the interaction of CASTOR2- containing heterodimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway. |
| Cellular Location | Cytoplasm, cytosol. |
| Tissue Location | Widely expressed.. |
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
The function of this protein remains unknown.
References
Hillier, L.W., et al. Nature 424(6945):157-164(2003)
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$ 150.00
$ 385.00
Cat# AP19129a
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