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HOXB13 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q92826 |
| Other Accession | Q1ECY2, P70321, NP_006352.2 |
| Reactivity | Mouse |
| Predicted | Zebrafish |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 30676 Da |
| Antigen Region | 223-251 aa |
| Gene ID | 10481 |
|---|---|
| Other Names | Homeobox protein Hox-B13, HOXB13 |
| Target/Specificity | This HOXB13 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 223-251 amino acids from the C-terminal region of human HOXB13. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | HOXB13 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | HOXB13 |
|---|---|
| Function | Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds preferentially to methylated DNA (PubMed:28473536). |
| Cellular Location | Nucleus. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a transcription factor that belongs to the homeobox gene family. Genes of this family are highly conserved among vertebrates and essential for vertebrate embryonic development. This gene has been implicated to play a role in fetal skin development and cutaneous regeneration. In mice, a similar gene was shown to exhibit temporal and spatial colinearity in the main body axis of the embryo, but was not expressed in the secondary axes, which suggests functions in body patterning along the axis. This gene and other HOXB genes form a gene cluster at chromosome the 17q21-22 region.
References
McMullin, R.P., et al. Proc. Natl. Acad. Sci. U.S.A. 107(1):98-103(2010)
Kim, Y.R., et al. Mol. Cancer 9, 124 (2010) :
Norris, J.D., et al. Mol. Cell 36(3):405-416(2009)
Goetz, M.P., et al. Clin. Cancer Res. 14(18):5864-5868(2008)
Rodriguez, B.A., et al. Carcinogenesis 29(7):1459-1465(2008)
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