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KAL1 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P23352 |
| Other Accession | NP_000207.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 76112 Da |
| Antigen Region | 166-194 aa |
| Gene ID | 3730 |
|---|---|
| Other Names | Anosmin-1, Adhesion molecule-like X-linked, Kallmann syndrome protein, KAL1, ADMLX, KAL, KALIG1 |
| Target/Specificity | This KAL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 166-194 amino acids from the N-terminal region of human KAL1. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | KAL1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ANOS1 (HGNC:6211) |
|---|---|
| Synonyms | ADMLX, KAL, KAL1, KALIG1 |
| Function | Has a dual branch-promoting and guidance activity, which may play an important role in the patterning of mitral and tufted cell collaterals to the olfactory cortex (By similarity). Chemoattractant for fetal olfactory epithelial cells. |
| Cellular Location | Cell membrane; Peripheral membrane protein. Secreted. Note=Proteolytic cleavage may release it from the cell surface into the extracellular space |
| Tissue Location | Expressed in the cerebellum (at protein level). |
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Provided below are standard protocols that you may find useful for product applications.
Background
Mutations in this gene cause the X-linked Kallmann syndrome. The encoded protein is similar in sequence to proteins known to function in neural cell adhesion and axonal migration. In addition, this cell surface protein is N-glycosylated and may have anti-protease activity.
References
Dode, C., et al. Ann. Endocrinol. (Paris) 71(3):149-157(2010)
Tengara, S., et al. J. Dermatol. Sci. 58(1):64-71(2010)
Jian, B., et al. Cell Cycle 8(22):3770-3776(2009)
Tang, K.F., et al. Asian J. Androl. 11(6):711-715(2009)
Hu, Y., et al. J. Biol. Chem. 284(43):29905-29920(2009)
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