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XK Antibody (N-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - XK Antibody (N-term) AP19173A
    XK Antibody (N-term) (Cat. #AP19173a) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the XK antibody detected the XK protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P51811
Other Accession Q5GH61, Q9QXY7, NP_066569.1
Reactivity Human
Predicted Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 50902 Da
Antigen Region 83-111 aa
Additional Information
Gene ID 7504
Other Names Membrane transport protein XK, Kell complex 37 kDa component, Kx antigen, XK-related protein 1, XK, XKR1, XRG1
Target/Specificity This XK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 83-111 amino acids from the N-terminal region of human XK.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsXK Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name XK {ECO:0000303|PubMed:8004674, ECO:0000312|HGNC:HGNC:12811}
Function Recruits the lipid transfer protein VPS13A from lipid droplets to the endoplasmic reticulum (ER) membrane.
Cellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein
Tissue Location High levels in skeletal muscle, heart, brain, and pancreas; low levels in placenta, lung, liver, and kidney
Research Areas
Citations (0)
citation

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Background

This locus controls the synthesis of the Kell blood group 'precursor substance' (Kx). Mutations in this gene have been associated with McLeod syndrome, an X-linked, recessive disorder characterized by abnormalities in the neuromuscular and hematopoietic systems. The encoded protein has structural characteristics of prokaryotic and eukaryotic membrane transport proteins.

References

Miranda, M., et al. Mov. Disord. 22(9):1358-1361(2007)
Claperon, A., et al. Brain Res. 1147, 12-24 (2007) :
Walker, R.H., et al. Transfusion 47(2):299-305(2007)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Jung, H.H., et al. Transfusion 43(7):928-938(2003)

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$ 182.50
$ 70.00
Cat# AP19173A
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