Foundational characteristics of cancer include proliferation, angiogenesis, migration, evasion of apoptosis, and cellular immortality. Find key markers for these cellular processes and antibodies to detect them.
The SUMOplot™ Analysis Program predicts and scores sumoylation sites in your protein. SUMOylation is a post-translational modification involved in various cellular processes, such as nuclear-cytosolic transport, transcriptional regulation, apoptosis, protein stability, response to stress, and progression through the cell cycle.
The Autophagy Receptor Motif Plotter predicts and scores autophagy receptor binding sites in your protein. Identifying proteins connected to this pathway is critical to understanding the role of autophagy in physiological as well as pathological processes such as development, differentiation, neurodegenerative diseases, stress, infection, and cancer.
Mouse Stk38 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q91VJ4 |
| Other Accession | Q15208, A2VDV2, NP_598876.1 |
| Reactivity | Mouse |
| Predicted | Bovine, Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 54174 Da |
| Antigen Region | 429-458 aa |
| Gene ID | 106504 |
|---|---|
| Other Names | Serine/threonine-protein kinase 38, NDR1 protein kinase, Nuclear Dbf2-related kinase 1, Stk38 {ECO:0000312|EMBL:AAH096581} |
| Target/Specificity | This Mouse Stk38 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 429-458 amino acids from the C-terminal region of mouse Stk38. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Mouse Stk38 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Stk38 {ECO:0000312|EMBL:AAH09658.1} |
|---|---|
| Function | Serine/threonine-protein kinase that acts as a negative regulator of MAP3K1/2 signaling (PubMed:21730291). Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2 (By similarity). Acts as an ufmylation 'reader' in a kinase-independent manner: specifically recognizes and binds mono-ufmylated histone H4 in response to DNA damage, promoting the recruitment of SUV39H1 to the double-strand breaks, resulting in ATM activation (By similarity). |
| Cellular Location | Nucleus {ECO:0000250|UniProtKB:Q15208}. Cytoplasm {ECO:0000250|UniProtKB:Q15208}. Chromosome {ECO:0000250|UniProtKB:Q15208}. Note=Localizes to DNA double-strand breaks in response to DNA damage. {ECO:0000250|UniProtKB:Q15208} |
| Tissue Location | Expressed at high levels in spleen, lung, thymus, brain and fat tissue. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
Negative regulator of MAP3K1/2 signaling. Converts MAP3K2 from its phosphorylated form to its nonphosphorylated form and inhibits autophosphorylation of MAP3K2 (By similarity).
References
Cornils, H., et al. Sci Signal 3 (126), RA47 (2010) :
Stegert, M.R., et al. J. Biol. Chem. 279(22):23806-23812(2004)
Stryke, D., et al. Nucleic Acids Res. 31(1):278-281(2003)
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.
Ordering Information
Other Products
Shipping Information
