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FOXN3 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 4
- PROTOCOLS
- BACKGROUND
Application 
| WB, IF, E |
|---|---|
| Primary Accession | O00409 |
| Other Accession | NP_005188.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 53835 Da |
| Antigen Region | 380-408 aa |
| Gene ID | 1112 |
|---|---|
| Other Names | Forkhead box protein N3, Checkpoint suppressor 1, FOXN3, C14orf116, CHES1 |
| Target/Specificity | This FOXN3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 380-408 amino acids from the C-terminal region of human FOXN3. |
| Dilution | WB~~1:2000 IF~~1:10~50 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | FOXN3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | FOXN3 |
|---|---|
| Synonyms | C14orf116, CHES1 |
| Function | Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cycle arrests (checkpoints). |
| Cellular Location | Nucleus. |
Provided below are standard protocols that you may find useful for product applications.
Background
This gene is a member of the forkhead/winged helix transcription factor family. Checkpoints are eukaryotic DNA damage-inducible cell cycle arrests at G1 and G2. Checkpoint suppressor 1 suppresses multiple yeast checkpoint mutations including mec1, rad9, rad53 and dun1 by activating a MEC1-independent checkpoint pathway. Alternative splicing is observed at the locus, resulting in distinct isoforms. [provided by RefSeq].
References
Samaan, G., et al. Biochem. Biophys. Res. Commun. 400(1):60-65(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
Markowski, J., et al. Eur Arch Otorhinolaryngol 266(10):1501-1507(2009)
Schlade-Bartusiak, K., et al. Am. J. Med. Genet. A 146A (1), 117-123 (2008) :
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