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SPINT2 Antibody (C-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - SPINT2 Antibody (C-term) AP19268b
    SPINT2 Antibody (C-term)(Cat. #AP19268b) western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the SPINT2 antibody detected the SPINT2 protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession O43291
Other Accession NP_066925.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 28228 Da
Antigen Region 222-251 aa
Additional Information
Gene ID 10653
Other Names Kunitz-type protease inhibitor 2, Hepatocyte growth factor activator inhibitor type 2, HAI-2, Placental bikunin, SPINT2, HAI2, KOP
Target/Specificity This SPINT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 222-251 amino acids from the C-terminal region of human SPINT2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSPINT2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SPINT2
Synonyms HAI2, KOP
Function Inhibitor of HGFAC (PubMed:9346890). Also inhibits plasmin, and plasma and tissue kallikrein (PubMed:9115294). Inhibits serine protease activity of TMPRSS13 (PubMed:20977675, PubMed:28710277). Inhibits serine protease activity of ST14/matriptase in vitro (PubMed:28710277).
Cellular Location Cell membrane; Single-pass type I membrane protein. Cytoplasm
Tissue Location Expressed in placenta, kidney, pancreas, prostate, testis, thymus, and trachea.
Research Areas
Citations (0)
citation

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Background

This gene encodes a transmembrane protein with two extracellular Kunitz domains that inhibits a variety of serine proteases. The protein inhibits HGF activator which prevents the formation of active hepatocyte growth factor. This gene is a putative tumor suppressor, and mutations in this gene result in congenital sodium diarrhea. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].

References

Dong, W., et al. Int. J. Cancer 127(7):1526-1534(2010)
Bergum, C., et al. Prostate 70(13):1422-1428(2010)
Sivagnanam, M., et al. Clin. Dysmorphol. 19 (1), 48 (2010) :
Yamauchi, M., et al. Biol. Chem. 383(12):1953-1957(2002)
Itoh, H., et al. Eur. J. Biochem. 267(11):3351-3359(2000)

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$ 182.50
$ 70.00
Cat# AP19268b
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