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VPREB1 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P12018 |
| Other Accession | NP_009059.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 16605 Da |
| Antigen Region | 71-99 aa |
| Gene ID | 7441 |
|---|---|
| Other Names | Immunoglobulin iota chain, CD179 antigen-like family member A, Protein VPreB1, V(pre)B protein, VpreB protein, CD179a, VPREB1, VPREB |
| Target/Specificity | This VPREB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 71-99 amino acids from the Central region of human VPREB1. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | VPREB1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | VPREB1 |
|---|---|
| Synonyms | VPREB |
| Function | Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells. This complex presumably regulates Ig gene rearrangements in the early steps of B- cell differentiation. |
| Cellular Location | Endoplasmic reticulum {ECO:0000250|UniProtKB:P13372} |
| Tissue Location | Only expressed by pre-B-cells. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene belongs to the immunoglobulin superfamily and is expressed selectively at the early stages of B cell development, namely, in proB and early preB cells. This gene encodes the iota polypeptide chain that is associated with the Ig-mu chain to form a molecular complex which is expressed on the surface of pre-B cells. The complex is thought to regulate Ig gene rearrangements in the early steps of B-cell differentiation.
References
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Wu, C., et al. Proteomics 7(11):1775-1785(2007)
Rossi, B., et al. J. Immunol. 177(2):796-803(2006)
Collins, J.E., et al. Genome Biol. 5 (10), R84 (2004) :
Gauthier, L., et al. Proc. Natl. Acad. Sci. U.S.A. 99(20):13014-13019(2002)
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