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TEKT3 Antibody(N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9BXF9 |
| Other Accession | A6H782, NP_114104.1 |
| Reactivity | Human |
| Predicted | Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 56636 Da |
| Antigen Region | 110-138 aa |
| Gene ID | 64518 |
|---|---|
| Other Names | Tektin-3, TEKT3 |
| Target/Specificity | This TEKT3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 110-138 amino acids from the N-terminal region of human TEKT3. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TEKT3 Antibody(N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TEKT3 |
|---|---|
| Function | Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme (PubMed:36191189). Forms filamentous polymers in the walls of ciliary and flagellar microtubules (By similarity). Required for normal sperm mobility (By similarity). |
| Cellular Location | Cytoplasm, cytoskeleton, cilium axoneme. Cell projection, cilium, flagellum. Cytoplasmic vesicle, secretory vesicle, acrosome outer membrane {ECO:0000250|UniProtKB:A6H782, ECO:0000250|UniProtKB:Q4V8G8}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q4V8G8}. Note=In spermatozoa, preferentially localizes to the flagella, but also found in the head (PubMed:36708031). In the sperm flagellum, localizes to the periaxonemal region where it associates with the mitochondrial sheath and outer dense fibers (By similarity). Not detected in the central axonemal region of the flagellum (By similarity). Associates with the acrosome membrane in the equatorial segment of the sperm head (By similarity). Also detected just below the plasma membrane in the post- acrosomal region where it might localize to the postacrosomal dense lamina (By similarity). However, other studies report little or no expression in the postacrosomal region (By similarity). Translocates from the postacrosomal region to the equatorial segment after sperm activation (By similarity). Retained in the postacromal region, but not the equatorial segment, following the acrosome reaction (By similarity). Some studies report strong expression in the anterior cap region (By similarity). However, other studies report little or no expression in the acrosomal cap (By similarity) {ECO:0000250|UniProtKB:A6H782, ECO:0000250|UniProtKB:Q4V8G8, ECO:0000269|PubMed:36708031} |
| Tissue Location | Expressed in spermatozoa (PubMed:36708031). Expressed in airway epithelial cells (PubMed:36191189) |
Research Areas
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
This gene product belongs to the tektin family of proteins. Tektins comprise a family of filament-forming proteins that are coassembled with tubulins to form ciliary and flagellar microtubules. The exact function of this gene is not known.
References
Wilk, J.B., et al. BMC Med. Genet. 8 SUPPL 1, S8 (2007) :
Roy, A., et al. Mol. Reprod. Dev. 67(3):295-302(2004)
Inoue, K., et al. Genome Res. 11(6):1018-1033(2001)
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$ 182.50
$ 70.00
Cat# AP19474a
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