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LHX4 Antibody(Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q969G2 |
| Other Accession | P53776, NP_203129.1 |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 43124 Da |
| Antigen Region | 133-161 aa |
| Gene ID | 89884 |
|---|---|
| Other Names | LIM/homeobox protein Lhx4, LIM homeobox protein 4, LHX4 |
| Target/Specificity | This LHX4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 133-161 amino acids from the Central region of human LHX4. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | LHX4 Antibody(Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | LHX4 |
|---|---|
| Function | May play a critical role in the development of respiratory control mechanisms and in the normal growth and maturation of the lung. Binds preferentially to methylated DNA (PubMed:28473536). |
| Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of a large protein family which contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator and be involved in control of differentiation and development of the pituitary gland. Mutations in this gene are associated with syndromic short stature and pituitary and hindbrain defects. An alternative splice variant has been described but its biological nature has not been determined.
References
Dateki, S., et al. J. Clin. Endocrinol. Metab. (2010) In press :
Castinetti, F., et al. J. Clin. Endocrinol. Metab. 93(7):2790-2799(2008)
Pfaeffle, R.W., et al. J. Clin. Endocrinol. Metab. 93(3):1062-1071(2008)
Liu, S., et al. Biochem. Biophys. Res. Commun. 366(1):36-41(2008)
de Bruijn, D.R., et al. Oncogene 27(5):653-662(2008)
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