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EPS8L2 Antibody(N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9H6S3 |
| Other Accession | Q99K30, NP_073609.2 |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 80621 Da |
| Antigen Region | 162-190 aa |
| Gene ID | 64787 |
|---|---|
| Other Names | Epidermal growth factor receptor kinase substrate 8-like protein 2, EPS8-like protein 2, Epidermal growth factor receptor pathway substrate 8-related protein 2, EPS8-related protein 2, EPS8L2, EPS8R2 |
| Target/Specificity | This EPS8L2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 162-190 amino acids from the N-terminal region of human EPS8L2. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | EPS8L2 Antibody(N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | EPS8L2 |
|---|---|
| Synonyms | EPS8R2 |
| Function | Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. In the cochlea, is required for stereocilia maintenance in adult hair cells (By similarity). |
| Cellular Location | Cytoplasm. Cell projection, stereocilium {ECO:0000250|UniProtKB:Q99K30}. Note=Localizes at the tips of the stereocilia of the inner and outer hair cells {ECO:0000250|UniProtKB:Q99K30} |
| Tissue Location | Detected in fibroblasts and placenta. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the EPS8 gene family. The encoded protein, like other members of the family, is thought to link growth factor stimulation to actin organization, generating functional redundancy in the pathways that regulate actin cytoskeletal remodeling.
References
Kim, J.E., et al. J. Proteome Res. 4(4):1339-1346(2005)
Offenhauser, N., et al. Mol. Biol. Cell 15(1):91-98(2004)
Tocchetti, A., et al. Genomics 81(2):234-244(2003)
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