GTPBP3 Antibody(Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | Q969Y2 |
Other Accession | NP_116009.2 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 52058 Da |
Antigen Region | 293-320 aa |
Gene ID | 84705 |
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Other Names | tRNA modification GTPase GTPBP3, mitochondrial, GTP-binding protein 3, Mitochondrial GTP-binding protein 1, GTPBP3, MTGP1 |
Target/Specificity | This GTPBP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 293-320 amino acids from the Central region of human GTPBP3. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | GTPBP3 Antibody(Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | GTPBP3 |
---|---|
Synonyms | MTGP1 |
Function | GTPase involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs. |
Cellular Location | Mitochondrion. |
Tissue Location | Ubiquitously expressed. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This locus encodes a GTP-binding protein. The encoded protein is localized to the mitochondria and may play a role in mitochondrial tRNA modification. Polymorphisms at this locus may be associated with severity of aminoglycoside-induced deafness, a disease associated with a mutation in the 12S rRNA. Alternatively spliced transcript variants encoding different isoforms have been described.
References
Reiling, E., et al. Eur. J. Hum. Genet. 17(8):1056-1062(2009)
Villarroya, M., et al. Mol. Cell. Biol. 28(24):7514-7531(2008)
Bykhovskaya, Y., et al. Mol. Genet. Metab. 83(3):199-206(2004)
Li, X., et al. Biochem. Biophys. Res. Commun. 312(3):747-754(2003)
Li, X., et al. Mol. Cell. Biol. 22(21):7701-7711(2002)
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