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USH1C Antibody(N-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - USH1C Antibody(N-term) AP19566a
    USH1C Antibody (N-term) (Cat. #AP19566a) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the USH1C antibody detected the USH1C protein (arrow).
    detail
  • WB - USH1C Antibody(N-term) AP19566a
    USH1C Antibody (N-term) (Cat. #AP19566a) western blot analysis in mouse NIH-3T3 cell line lysates (35ug/lane).This demonstrates the USH1C antibody detected the USH1C protein (arrow).
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q9Y6N9
Other Accession Q9ES64, Q3MHQ0, NP_005700.2
Reactivity Human, Mouse
Predicted Bovine
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 62211 Da
Antigen Region 1-30 aa
Additional Information
Gene ID 10083
Other Names Harmonin, Antigen NY-CO-38/NY-CO-37, Autoimmune enteropathy-related antigen AIE-75, Protein PDZ-73, Renal carcinoma antigen NY-REN-3, Usher syndrome type-1C protein, USH1C, AIE75
Target/Specificity This USH1C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human USH1C.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsUSH1C Antibody(N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name USH1C
Synonyms AIE75
Function Anchoring/scaffolding protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal development and maintenance of cochlear hair cell bundles (By similarity). As part of the intermicrovillar adhesion complex/IMAC plays a role in brush border differentiation, controlling microvilli organization and length. Probably plays a central regulatory role in the assembly of the complex, recruiting CDHR2, CDHR5 and MYO7B to the microvilli tips (PubMed:24725409, PubMed:26812018).
Cellular Location Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Cell projection, microvillus. Note=Colocalizes with F-actin (By similarity). Detected at the tip of cochlear hair cell stereocilia (By similarity). Enriched in microvilli of the intestinal brush border (PubMed:24725409). {ECO:0000250|UniProtKB:Q9ES64, ECO:0000269|PubMed:24725409}
Tissue Location Expressed in small intestine, colon, kidney, eye and weakly in pancreas. Expressed also in vestibule of the inner ear
Research Areas
Citations (0)
citation

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Background

This gene encodes a scaffold protein that functions in the assembly of Usher protein complexes. The protein contains PDZ domains, a coiled-coil region with a bipartite nuclear localization signal and a PEST degradation sequence. Defects in this gene are the cause of Usher syndrome type 1C and non-syndromic sensorineural deafness autosomal recessive type 18. Multiple transcript variants encoding different isoforms have been found for this gene.

References

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Yan, J., et al. Proc. Natl. Acad. Sci. U.S.A. 107(9):4040-4045(2010)
Jaijo, T., et al. Invest. Ophthalmol. Vis. Sci. 51(3):1311-1317(2010)
Pan, L., et al. Proc. Natl. Acad. Sci. U.S.A. 106(14):5575-5580(2009)
Baux, D., et al. Hum. Mutat. 29 (8), E76-E87 (2008) :

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$ 182.50
$ 70.00
Cat# AP19566a
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