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Dcr-1 Antibody (Center)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P34529 |
| Reactivity | C.Elegans |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 218423 Da |
| Antigen Region | 1068-1097 aa |
| Gene ID | 176138 |
|---|---|
| Other Names | Endoribonuclease dcr-1, 3126-, dcr-1 |
| Target/Specificity | This Dcr-1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1068-1097 amino acids of CAEEL Dcr-1. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Dcr-1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | dcr-1 {ECO:0000303|PubMed:11641272, ECO:0000312|WormBase:K12H4.8} |
|---|---|
| Function | Component of the ERI/DICER complex which is involved in processing amplified double-stranded RNA (dsRNA) intermediates during small-RNA-mediated gene-silencing or RNA interference (RNAi) (Probable). Involved in cleaving dsRNA in the RNAi pathway (PubMed:11641272, PubMed:20223951). It produces 21 to 23 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs (PubMed:11641272, PubMed:20223951). Seems to process the precursor of the small temporal RNA let-7 which is involved in developmental timing (PubMed:11641272). Required for avoidance behavior induced by small RNAs derived from pathogenic bacteria such as P.aeruginosa (PubMed:32908307). Involved in innate immunity through its role in small RNA processing. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The Dcr-1 gene encodes a bidentate ribonuclease that is homologous to E. coli RNAse III. Dcr-1 is required both for RNA interference and for synthesis of small developmental RNAs. Dcr-1 interacts in vivo with RDE-4, a double-stranded RNA (dsRNA) binding protein required for RNAi that interacts with trigger dsRNAs and may function to deliver dsRNAs to Dcr-1 for endonucleolytic processing.
References
Duchaine TF, et al. 2006. Cell 124:343-354.
Denli AM, et al. 2004. Nature 432:231-235.
Tabara H, et al. 2002. Cell 109:861-871.
Grishok A, et al. 2001. Cell 106:23-34.
Knight SW, et al. 2001. Science 293:2269-2271.
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