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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   COLQ Antibody(C-term)   

COLQ Antibody(C-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - COLQ Antibody(C-term) AP19625b
    COLQ Antibody (C-term) (Cat. #AP19625b) western blot analysis in mouse stomach tissue lysates (35ug/lane).This demonstrates the COLQ antibody detected the COLQ protein (arrow).
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  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q9Y215
Other Accession O35167, O35348, NP_536800.2
Reactivity Human, Mouse
Predicted Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 47766 Da
Antigen Region 324-353 aa
Additional Information
Gene ID 8292
Other Names Acetylcholinesterase collagenic tail peptide, AChE Q subunit, Acetylcholinesterase-associated collagen, COLQ
Target/Specificity This COLQ antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 324-353 amino acids from the C-terminal region of human COLQ.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCOLQ Antibody(C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name COLQ
Function Anchors the catalytic subunits of asymmetric AChE to the synaptic basal lamina.
Cellular Location Synapse.
Tissue Location Found at the end plate of skeletal muscle.
Research Areas
Citations (0)
citation

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Background

This gene encodes the subunit of a collagen-like molecule associated with acetylcholinesterase in skeletal muscle. Each molecule is composed of three identical subunits. Each subunit contains a proline-rich attachment domain (PRAD) that binds an acetylcholinesterase tetramer to anchor the catalytic subunit of the enzyme to the basal lamina. Mutations in this gene are associated with endplate acetylcholinesterase deficiency. Multiple transcript variants encoding different isoforms have been found for this gene.

References

Mihaylova, V., et al. Brain 131 (PT 3), 747-759 (2008) :
Schreiner, F., et al. Neuromuscul. Disord. 17(3):262-265(2007)
Ting, A.K., et al. Chem. Biol. Interact. 157-158, 63-70 (2005) :
Dvir, H., et al. EMBO J. 23(22):4394-4405(2004)
Ishigaki, K., et al. Neuromuscul. Disord. 13(3):236-244(2003)

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$ 182.50
$ 70.00
Cat# AP19625b
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