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HDAC1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q13547, Q4QQW4 |
| Other Accession | Q4QQW4, O09106, Q32PJ8, NP_004955.2, Q13547 |
| Reactivity | Human, Rat |
| Predicted | Bovine, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Antigen Region | 421-450 aa |
| Other Names | Histone deacetylase 1, HD1, HDAC1, RPD3L1 |
|---|---|
| Target/Specificity | This HDAC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 421-450 amino acids from the C-terminal region of human HDAC1. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | HDAC1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.
References
Yang, Z., et al. Clin. Chem. Lab. Med. 48(12):1785-1791(2010)
Grausenburger, R., et al. J. Immunol. 185(6):3489-3497(2010)
Miller, K.M., et al. Nat. Struct. Mol. Biol. 17(9):1144-1151(2010)
Brandt, S., et al. Int. J. Biochem. Cell Biol. 42(9):1472-1481(2010)
Leone, V., et al. Oncogene 29(30):4341-4351(2010)
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