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SETD3 Antibody(C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q86TU7 |
| Other Accession | NP_115609.2, NP_954574.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 67257 Da |
| Antigen Region | 556-585 aa |
| Gene ID | 84193 |
|---|---|
| Other Names | Histone-lysine N-methyltransferase setd3, SET domain-containing protein 3, SETD3, C14orf154 |
| Target/Specificity | This SETD3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 556-585 amino acids from the C-terminal region of human SETD3. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SETD3 Antibody(C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SETD3 |
|---|---|
| Function | Protein-histidine N-methyltransferase that specifically mediates 3-methylhistidine (tele-methylhistidine) methylation of actin at 'His-73' (PubMed:30526847, PubMed:30626964, PubMed:30785395, PubMed:31388018, PubMed:31993215). Histidine methylation of actin is required for smooth muscle contraction of the laboring uterus during delivery (PubMed:30626964). Does not have protein-lysine N- methyltransferase activity and probably only catalyzes histidine methylation of actin (PubMed:30626964, PubMed:30785395, PubMed:31388018). |
| Cellular Location | Cytoplasm. Nucleus Note=Localizes mainly in the cytoplasm. |
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Provided below are standard protocols that you may find useful for product applications.
Background
SETD3 contains 1 SET domain. The function of the SETD3 protein remains unknown. There are 3 isoforms produced by alternative splicing.
References
Tao, W.A., et al. Nat. Methods 2(8):591-598(2005)
Tao, W.A., et al. Nat. Methods 2(8):591-598(2005)
Harrington, J.J., et al. Nat. Biotechnol. 19(5):440-445(2001)
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