CLSTN2 Antibody(Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q9H4D0 |
Other Accession | NP_071414.2 |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 107006 Da |
Antigen Region | 743-770 aa |
Gene ID | 64084 |
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Other Names | Calsyntenin-2, Alcadein-gamma, Alc-gamma, CLSTN2, CS2 |
Target/Specificity | This CLSTN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 743-770 amino acids from the Central region of human CLSTN2. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | CLSTN2 Antibody(Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CLSTN2 (HGNC:17448) |
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Synonyms | CS2 |
Function | Postsynaptic adhesion molecule that binds to presynaptic neurexins to mediate synapse formation, and which is involved in learning and memory (By similarity). Promotes synapse development by acting as a cell adhesion molecule at the postsynaptic membrane, which associates with neurexin-alpha at the presynaptic membrane (By similarity). |
Cellular Location | Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q9ER65}; Single-pass type I membrane protein. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9ER65}; Single-pass type I membrane protein. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9ER65}; Single-pass type I membrane protein. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9ER65}. Note=Most prominent in the postsynaptic specializations of asymmetric (type I) synapses with both axodendritic and axospinous localization {ECO:0000250|UniProtKB:Q9ER65} |
Tissue Location | Restricted to the brain. |
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Provided below are standard protocols that you may find useful for product applications.
Background
CLSTN2 may modulate calcium-mediated postsynaptic signals (By similarity).
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Preuschhof, C., et al. Neuropsychologia 48(2):402-408(2010)
Zhang, H., et al. Neuropsychopharmacology 34(12):2508-2516(2009)
Henckaerts, L., et al. Clin. Gastroenterol. Hepatol. 7(9):972-980(2009)
Jacobsen, L.K., et al. Biol. Psychiatry 65(8):671-679(2009)
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