UFC1 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q9Y3C8 |
Other Accession | Q6BBI8, Q9CR09, Q5E953, NP_057490.2 |
Reactivity | Human |
Predicted | Bovine, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 19458 Da |
Antigen Region | 2-31 aa |
Gene ID | 51506 |
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Other Names | Ubiquitin-fold modifier-conjugating enzyme 1, Ufm1-conjugating enzyme 1, UFC1 |
Target/Specificity | This UFC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 2-31 amino acids from the N-terminal region of human UFC1. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | UFC1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | UFC1 {ECO:0000303|PubMed:15071506, ECO:0000312|HGNC:HGNC:26941} |
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Function | E1-like enzyme which specifically catalyzes the second step in ufmylation (PubMed:15071506, PubMed:29868776). Accepts the ubiquitin-like modifier UFM1 from the E1 enzyme UBA5 and forms an intermediate with UFM1 via a thioester linkage (PubMed:15071506, PubMed:29868776). Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress (PubMed:32160526). |
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Provided below are standard protocols that you may find useful for product applications.
Background
UFC1 is an E2-like conjugating enzyme for ubiquitin-fold modifier-1 (UFM1; MIM 610553) (Komatsu et al., 2004 [PubMed 15071506]).
References
Liu, G., et al. J. Struct. Funct. Genomics 10(2):127-136(2009)
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
Komatsu, M., et al. EMBO J. 23(9):1977-1986(2004)
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