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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   LGALS3BP Antibody (Center)   

LGALS3BP Antibody (Center)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - LGALS3BP Antibody (Center) AP19780c
    All lanes : Anti-LGALS3BP Antibody (Center) at 1:2000 dilution Lane 1: Human liver tissue lysate Lane 2: Mouse lung tissue lysate Lane 3: Human plasma tissue lysate Lane 4: NIH/3T3 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 65 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • WB - LGALS3BP Antibody (Center) AP19780c
    All lanes : Anti-LGALS3BP Antibody (Center) at 1:2000 dilution Lane 1: Hela whole cell lysate Lane 2: Human plasma lysate Lane 3: Mouse lung lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 65 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • IHC-P-Leica - LGALS3BP Antibody (Center) AP19780c
    Immunohistochemical analysis of AP19780C on paraffin-embedded Human prostate tissue was performed on the Leica® BOND RXm. Tissue was fixed with formaldehyde at room temperature. Heat induced epitope retrieval was performed by EDTA buffer (pH9. 0). Samples were incubated with primary antibody(1:100) for 15min at room temperature. Leica Bond Polymer Refine Detection was used as the secondary antibody.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P-Leica, WB, E
Primary Accession Q08380
Other Accession NP_005558.1
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 65331 Da
Antigen Region 383-412 aa
Additional Information
Gene ID 3959
Other Names Galectin-3-binding protein, Basement membrane autoantigen p105, Lectin galactoside-binding soluble 3-binding protein, Mac-2-binding protein, MAC2BP, Mac-2 BP, Tumor-associated antigen 90K, LGALS3BP, M2BP
Target/Specificity This LGALS3BP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 383-412 amino acids from the Central region of human LGALS3BP.
Dilution WB~~1:2000
IHC-P-Leica~~1:100
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsLGALS3BP Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name LGALS3BP
Synonyms M2BP
Function Promotes integrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells.
Cellular Location Secreted. Secreted, extracellular space, extracellular matrix
Tissue Location Ubiquitous. Detected in body fluids such as semen, milk, serum, tears, saliva and urine. Expressed by keratinocytes and fibroblasts.
Research Areas
Citations (0)

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Background

The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. LGALS3BP has been found elevated in the serum of patients with cancer and in those infected by the human immunodeficiency virus (HIV). It appears to be implicated in immune response associated with natural killer (NK) and lymphokine-activated killer (LAK) cell cytotoxicity. Using fluorescence in situ hybridization the full length 90K cDNA has been localized to chromosome 17q25. The native protein binds specifically to a human macrophage-associated lectin known as Mac-2 and also binds galectin 1.

References

Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Srirajaskanthan, R., et al. Mol. Cell Proteomics 9(4):656-666(2010)
Zambelli, D., et al. Int. J. Cancer 126(1):41-52(2010)
Lee, J.H., et al. Pathology 41(3):229-233(2009)
Kim, S.J., et al. Acta Haematol. 120(4):211-216(2008)

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$ 175.00
$ 58.50
Cat# AP19780c
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