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MTHFR Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P42898 |
| Other Accession | Q9WU20, Q60HE5, Q5I598, NP_005948.3 |
| Reactivity | Human |
| Predicted | Bovine, Monkey, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 74597 Da |
| Antigen Region | 266-292 aa |
| Gene ID | 4524 |
|---|---|
| Other Names | Methylenetetrahydrofolate reductase, MTHFR |
| Target/Specificity | This MTHFR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 266-292 amino acids from the Central region of human MTHFR. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MTHFR Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MTHFR (HGNC:7436) |
|---|---|
| Function | Catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a cosubstrate for homocysteine remethylation to methionine (PubMed:29891918). Represents a key regulatory connection between the folate and methionine cycles (Probable). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine. Genetic variation in this gene influences susceptibility to occlusive vascular disease, neural tube defects, colon cancer and acute leukemia, and mutations in this gene are associated with methylenetetrahydrofolate reductase deficiency.
References
Singh, K., et al. J Postgrad Med 56(4):267-269(2010)
Harisha, P.N., et al. J Neurosurg Pediatr 6(4):364-367(2010)
Wu, H.C., et al. Anticancer Res. 30(9):3573-3577(2010)
Magnowski, P., et al. Ginekol. Pol. 81(7):506-510(2010)
Kristensen, M.H., et al. J. Int. Med. Res. 38(3):870-883(2010)
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