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NLN Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9BYT8 |
| Other Accession | NP_065777.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 80652 Da |
| Antigen Region | 212-240 aa |
| Gene ID | 57486 |
|---|---|
| Other Names | Neurolysin, mitochondrial, Angiotensin-binding protein, Microsomal endopeptidase, MEP, Mitochondrial oligopeptidase M, Neurotensin endopeptidase, NLN, AGTBP, KIAA1226 |
| Target/Specificity | This NLN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 212-240 amino acids from the Central region of human NLN. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | NLN Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NLN |
|---|---|
| Synonyms | AGTBP, KIAA1226 |
| Function | Hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin A (By similarity). Acts as a regulator of cannabinoid signaling pathway by mediating degradation of hemopressin, an antagonist peptide of the cannabinoid receptor CNR1 (By similarity). |
| Cellular Location | Mitochondrion intermembrane space {ECO:0000250|UniProtKB:P42676}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:P42676} |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the metallopeptidase M3 protein family that cleaves neurotensin at the Pro10-Tyr11 bond, leading to the formation of neurotensin(1-10) and neurotensin(11-13). The encoded protein is likely involved in the termination of the neurotensinergic signal in the central nervous system and in the gastrointestinal tract.
References
Rose, J. Phd, et al. Mol. Med. (2010) In press :
Lim, E.J., et al. J. Biol. Chem. 282(13):9722-9732(2007)
Norman, M.U., et al. Am. J. Physiol. Heart Circ. Physiol. 284 (6), H1978-H1984 (2003) :
Norman, M.U., et al. Am. J. Physiol. Heart Circ. Physiol. 284 (6), H1978-H1984 (2003) :
Garrido, P.A., et al. DNA Cell Biol. 18(4):323-331(1999)
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