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PIGB Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q92521 |
| Other Accession | NP_004846.4 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 65056 Da |
| Antigen Region | 28-56 aa |
| Gene ID | 9488 |
|---|---|
| Other Names | GPI mannosyltransferase 3, 241-, GPI mannosyltransferase III, GPI-MT-III, Phosphatidylinositol-glycan biosynthesis class B protein, PIG-B, PIGB |
| Target/Specificity | This PIGB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 28-56 amino acids from the N-terminal region of human PIGB. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PIGB Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PIGB (HGNC:8959) |
|---|---|
| Function | Alpha-1,2-mannosyltransferase that catalyzes the transfer of the third mannose, via an alpha-1,2 bond, from a dolichol-phosphate- mannose (Dol-P-Man) to an alpha-D-Man-(1->6)-2-PEtn-alpha-D-Man-(1->4)- alpha-D-GlcN-(1->6)-(1-radyl,2-acyl-sn-glycero-3-phospho)-2-acyl- inositol intermediate to generate an alpha-D-Man-(1->2)-alpha-D-Man- (1->6)-2-PEtn-alpha-D-Man-(1->4)-alpha-D-GlcN-(1->6)-(1-radyl,2-acyl- sn-glycero-3-phospho)-2-acyl-inositol (also termed H6) and participates in the nineth step of the glycosylphosphatidylinositol-anchor biosynthesis (PubMed:8861954). May also add the third mannose to an alpha-D-Man-(1->6)-alpha-D-Man-(1->4)-alpha-D-GlcN-(1->6)-(1-radyl,2- acyl-sn-glycero-3-phospho)-2-acyl-inositol (also termed H3) intermediate generating an alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-alpha- D-Man-(1->4)-alpha-D-GlcN-(1->6)-(1-radyl,2-acyl-sn-glycero-3-phospho)- 2-acyl-inositol (also termed H4) (Probable). |
| Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a transmembrane protein that is located in the endoplasmic reticulum and is involved in GPI-anchor biosynthesis. The glycosylphosphatidylinositol (GPI) anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This gene is thought to encode a member of a family of dolichol-phosphate-mannose (Dol-P-Man) dependent mannosyltransferases.
References
Rose, J. Phd, et al. Mol. Med. (2010) In press :
Hwang, G.W., et al. J Toxicol Sci 32(5):581-583(2007)
Anikster, Y., et al. Am. J. Hum. Genet. 71(2):407-414(2002)
Kinoshita, T., et al. Curr Opin Chem Biol 4(6):632-638(2000)
Takahashi, M., et al. EMBO J. 15(16):4254-4261(1996)
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