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CCT7 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q99832 |
| Other Accession | P80313, Q5ZJK8, Q2NKZ1, NP_006420.1 |
| Reactivity | Human |
| Predicted | Bovine, Chicken, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 59367 Da |
| Antigen Region | 64-92 aa |
| Gene ID | 10574 |
|---|---|
| Other Names | T-complex protein 1 subunit eta, TCP-1-eta, CCT-eta, HIV-1 Nef-interacting protein, CCT7, CCTH, NIP7-1 |
| Target/Specificity | This CCT7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 64-92 amino acids from the N-terminal region of human CCT7. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CCT7 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CCT7 |
|---|---|
| Synonyms | CCTH, NIP7-1 |
| Function | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). The TRiC complex plays a role in the folding of actin and tubulin (Probable). |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:P80313}. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 5 and 6.
References
Mukherjee, K., et al. BMC Evol. Biol. 10, 64 (2010) :
Zebol, J.R., et al. Int. J. Biochem. Cell Biol. 41(4):822-827(2009)
Guo, D., et al. Biochem. Biophys. Res. Commun. 337(4):1308-1318(2005)
Hanafy, K.A., et al. J. Biol. Chem. 279(45):46946-46953(2004)
Imai, Y., et al. J. Biol. Chem. 278(51):51901-51910(2003)
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