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CNBP Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | P62633 |
| Other Accession | P62634, P53996, O42395, Q3T0Q6, NP_001120665.1 |
| Reactivity | Human, Rat |
| Predicted | Bovine, Chicken, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 19463 Da |
| Antigen Region | 91-118 aa |
| Gene ID | 7555 |
|---|---|
| Other Names | Cellular nucleic acid-binding protein, CNBP, Zinc finger protein 9, CNBP, RNF163, ZNF9 |
| Target/Specificity | This CNBP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 91-118 amino acids from the Central region of human CNBP. |
| Dilution | WB~~1:1000 IHC-P~~1:25 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CNBP Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CNBP (HGNC:13164) |
|---|---|
| Synonyms | RNF163, ZNF9 |
| Function | Single-stranded DNA-binding protein that preferentially binds to the sterol regulatory element (SRE) sequence 5'-GTGCGGTG-3', and thereby mediates transcriptional repression (PubMed:2562787). Has a role as transactivator of the Myc promoter (By similarity). Binds single-stranded RNA in a sequence-specific manner (By similarity). |
| Cellular Location | Nucleus {ECO:0000250|UniProtKB:P53996}. Cytoplasm. Endoplasmic reticulum {ECO:0000250|UniProtKB:P53996} [Isoform 2]: Cytoplasm [Isoform 5]: Cytoplasm [Isoform 8]: Cytoplasm |
| Tissue Location | Expressed in the liver, kidney, spleen, testis, lung, muscle and adrenal glands. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a nucleic-acid binding protein with seven zinc-finger domains. The protein has a preference for binding single stranded DNA and RNA. The protein functions in cap-independent translation of ornithine decarboxylase mRNA, and may also function in sterol-mediated transcriptional regulation. A CCTG expansion in the first intron of this gene results in myotonic dystrophy type 2. Multiple transcript variants encoding different isoforms have been found for this gene.
References
Catalli, C., et al. J Mol Diagn 12(5):601-606(2010)
Massa, R., et al. Neuropathol. Appl. Neurobiol. 36(4):275-284(2010)
Sammons, M.A., et al. PLoS ONE 5 (2), E9301 (2010) :
Lucchiari, S., et al. J. Neurol. Sci. 275 (1-2), 159-163 (2008) :
Auvinen, S., et al. Arthritis Rheum. 58(11):3627-3631(2008)
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