RECQL Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | P46063 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 73457 Da |
Antigen Region | 187-215 aa |
Gene ID | 5965 |
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Other Names | ATP-dependent DNA helicase Q1, DNA helicase, RecQ-like type 1, RecQ1, DNA-dependent ATPase Q1, RecQ protein-like 1, RECQL, RECQ1, RECQL1 |
Target/Specificity | This RECQL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 187-215 amino acids from the Central region of human RECQL. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | RECQL Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | RECQL {ECO:0000303|PubMed:7961977} |
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Synonyms | RECQ1, RECQL1 |
Function | DNA helicase that plays a role in DNA damage repair and genome stability (PubMed:7961977, PubMed:7527136, PubMed:8056767, PubMed:15886194, PubMed:35025765). Exhibits a magnesium- and ATP- dependent DNA-helicase activity that unwinds single- and double- stranded DNA in a 3'-5' direction (PubMed:7527136, PubMed:8056767, PubMed:35025765, PubMed:19151156). Full-length protein unwinds forked DNA substrates, resolves Holliday junctions, and has DNA strand annealing activity (PubMed:19151156, PubMed:25831490). Plays a role in restoring regressed replication forks (PubMed:35025765). Required to restart stalled replication forks induced by abortive topoisomerase 1 and 2 lesions (PubMed:35025765). May play a role in the repair of DNA that is damaged by ultraviolet light or other mutagens (PubMed:7961977, PubMed:15886194). |
Cellular Location | Nucleus |
Tissue Location | High expression in heart, lung, skeletal muscle and kidney, low expression in brain. |
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Provided below are standard protocols that you may find useful for product applications.
Background
DNA helicase that may play a role in the repair of DNA that is damaged by ultraviolet light or other mutagens. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single-and double-stranded DNA in a 3'-5' direction.
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