|Application ||IHC-P, WB, E|
|Calculated MW||72232 Da|
|Antigen Region||570-599 aa|
|Other Names||LIM domain kinase 2, LIMK-2, LIMK2|
|Target/Specificity||This LIMK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 570-599 amino acids from the C-terminal region of human LIMK2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||LIMK2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics (PubMed:10436159, PubMed:11018042). Acts downstream of several Rho family GTPase signal transduction pathways (PubMed:10436159, PubMed:11018042). Involved in astral microtubule organization and mitotic spindle orientation during early stage of mitosis by mediating phosphorylation of TPPP (PubMed:22328514). Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro (PubMed:8537403).|
|Cellular Location||Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle [Isoform LIMK2b]: Cytoplasm. Nucleus Note=Isoform LIMK2b occurs mainly in the cytoplasm and is scarcely translocated to the nucleus.|
|Tissue Location||Highest expression in the placenta; moderate level in liver, lung, kidney, and pancreas. LIMK2a is found to be more abundant then LIMK2b in liver, colon, stomach, and spleen, while in brain, kidney, and placenta LIMK2b is the dominant form. In adult lung, both LIMK2a and LIMK2b is nearly equally observed|
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Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro.
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