GINS3 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q9BRX5 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 24535 Da |
Antigen Region | 190-216 aa |
Gene ID | 64785 |
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Other Names | DNA replication complex GINS protein PSF3, GINS complex subunit 3, GINS3, PSF3 |
Target/Specificity | This GINS3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 190-216 amino acids from the C-terminal region of human GINS3. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | GINS3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | GINS3 (HGNC:25851) |
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Synonyms | PSF3 |
Function | Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks (PubMed:17417653, PubMed:28414293). GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232). |
Cellular Location | Nucleus. Chromosome. Note=Associates with chromatin |
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Provided below are standard protocols that you may find useful for product applications.
Background
The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA.
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